Patients from all over the world have been seeking Dr Gulani's services and eye surgeons have been flying in to Jacksonville to learn from his techniques and instrumentations.
Dr. Gulani in the Medical Media
Pterygia and pingueculae are intriguing and some of the oldest pathologies that ophthalmologists confront. Presentations vary in various tissue distributions and vascular patterns from small atrophic lesions to large aggressive vision-compromising fibrovascular growths advanced cases.
What started over a decade ago with celebrities, news anchors, and models seeking our services for cosmetic outcomes of their pterygium surgery has become a common demand of men and women from all walks of life. We see a fair number of professional golfers, surfers, and avid outdoor enthusiasts.
Although prolonged sun exposure is thought to cause pterygium and pinguecula formation, his 20-year experience with patients from the U.S. and worldwide points toward a genetic predilection that was confirmed by observation of bitemporal growths (in both eyes) in children in equatorial countries where we perform pro bono work.
While cosmetic symptoms can seem trivial to ophthalmologists, patient concerns are genuine and range from self-consciousness, low self-esteem, and embarrassment to depression as a result of their ocular appearance. This realization fueled the desire to continuously raise the bar on ocular surface surgery to a cosmetic outcome.
As in LASIK and cataract surgeries in which we aim for spectacle-free vision with a flawless looking eye, we instruct fellows and visiting surgeons that at every step in ocular surface surgery they should constantly think of how they want this patient to look immediately postoperatively and years later. Removing the lesion is one goal and beautifying the eye (with minimal visual impact) is the other goal, but both are essential.
Considering the consistent outcomes of our pterygial surgery, patients have been actively seeking pinguecula correction.
Over two decades, we have classified pterygia4 into categories (based on head/neck adhesion, vascular pattern, and draw test) and continuously study the presentations and outcomes to improve technique and results. This also underscores the fact that pterygial appearance and size do not predict the surgical ease or outcome.
We have honed the “Iceberg Technique” over 2 decades based on more than 700 surgeries, with consistent results. The surgery earned that name because the visible part of the pterygium is just the tip of the iceberg, and the actual growth tends to be much deeper. The surgery enables patients with cosmetic pterygia and pinguecula and those with recurrent and aggressive vision-threatening pterygia to expect clear, white eyes starting day 1 postoperatively.
We started out originally with a sutured technique,5 and evolved it to include amniotic grafting with due credit to Dr. Tseng’s work which we incorporated 14 years ago. we then aspired to make it sutureless using the Tisseel Glue (Baxter International) and finally to today’s cosmetic outcomes with refractively neutral endpoints.
Though we have used all kinds of amniotic grafts in the wide spectrum of Cryopreserved and dehydrated varieties, such as Amniograft (BioTissue/TissueTech), Ambiodry (IOP/Katena), and other newer ones on the market including those in research and development internationally, amniotic graft of choice continues to be the Amniograft.
The Iceberg Technique neither threatens nor adversely affects vision because no corneal incisions are made. While the average pterygial recurrence rate hovers near 39%, that with the Iceberg technique has been less than 0.5%.
In a typical case, anesthesia is induced with topical tetracaine hydrochloride (Tetravisc Forte, Sigma Pharmaceuticals) applied preoperatively with topical moxifloxacin (Vigamox, Alcon Pharmaceuticals). Intra-lesional anesthesia (1-2 cc of lidocaine with epinephrine) is used. Recently, patients have been requesting laryngeal mask airway anesthesia. Given that most of these patients are young and healthy and sometimes require extensive surgery, this anesthesia facilitates a comfortable experience and safe recovery.
Depending on the appearance and draw test, we approach the pterygium at the contracted medial conjunctival fold and proceed medially to limbally or from the head toward the medial conjunctival fold.
The head of the pterygium first is delineated under the cornea with a posterior-to-anterior sweep using the Gulani Pterygium Cross-Action Spreader (Storz). In cases with mild adhesions, the pterygium can be separated easily from the cornea (mostly peripheral pterygia and those in elderly patients) or peeled in one centrifugal movement.
After corneal smoothing with a specially designed blunt blade, remnant tissue (especially with gritty pterygia) is meticulously removed with a toothed forceps medially to limbally. The blade is used to smooth the limbus. A wek-cel sponge soaked in 1:1000 epinephrine is tucked into the nasal crevice where the cut pterygium is pressured into hemostasis. When this step is completed, the field is free of blood for dissection. Another benefit is that a space has been created in which to tuck the amniotic graft.
Pterygial dissection is the most important step. The entire pterygial plane is delineated subconjunctivally as if separating a fan-shaped scar with tentacles into the fornices and medial angle. The pterygium is pulled superiorly and vertically to avoid damaging the underlying medial rectus. By cutting vertically instead of horizontally, unnecessary involvement of orbital fat, bleeding, and iatrogenic damage to the medial rectus is avoided.
Upon removal, the pterygium resembles a spreading mass of tentacles. It is important to remove the entire mass to avoid recurrence.
The pterygium is dissected superiorly to avoid buttonholing the conjunctiva and invading the orbital septum and inferiorly to avoid cutting the underlying muscles, which is rechecked after the pterygium is removed.
There is no to minimal intraoperative bleeding. Cautery is performed sparingly and only for cosmetic reasons.
Surgeons should patiently pick at the episcleral remnants to clear the underlying sclera to remove all pterygial tissue from the area of impact. Pieces of wek-cel sponges are soaked in mitomycin C (MMC) 0.04% and placed under the conjunctiva in the area of the dissection for 30 seconds. MMC application on the sclera should be avoided and the sclera dried with a clean wek-cel sponge. After removing all sponges, the area is flushed copiously with balanced salt solution.
The cornea functions as an illuminated receiving table on which to drape the amniotic membrane, which is placed on the raw area and accepted with a Tyre-Tool technique. This eliminates touching the membrane with any instrument, so that it slips under the surrounding cut conjunctival edge medially, superiorly, and inferiorly.
The amniotic graft is milked to adhere to the global contour using a specially designed forceps that squeegees the graft on the sclera. Tisseel Glue is applied under the membrane as two separate components, and the membrane is squeegeed again in two quick sweeps to a pearly white and smooth appearance. The conjunctiva and underlying tenons are glued; they are closed in a C-shape with medial facing convexity to ensure closure of any potential space in between.
The fornices are checked for excessive glue, which can cause irritation and keratitis on the first postoperative day, and cleared with a forceps sweep. The same blade is used in one sweep to cut the excess graft at the limbus. The excess graft is peeled as it clears the cornea and also confirms adhesion of the remaining graft. This ensures that there is no bumpy anatomy at the limbus and patients can resume contact lens wear early postoperatively or undergo laser vision surgery in the near future.
In extensive cases with medial corneal epithelial defects (resulting from peeling of an aggressive pterygium head), we suggest Prokera (BioTissue) or Ambiodisc (Katena) in addition in the postoperative period.
All patients are instructed to look at their eye in a mirror on day 1 postoperatively. We observe their exclamations/reactions, which while always gratifying, vary tremendously based on their cultures and personalities. Most patients are satisfied with their aesthetic results within 24 hours and return to daily activities within a couple of days.
Turning non-candidates into candidates.
The importance of this technique goes beyond successfully treating pterygium and pinguecula and achieving sparkling white eyes 1 day postoperatively. In fact, it is a technique that turns non-candidates who had previously undergone a LASIK or premium IOL cataract surgery with tissue-induced irregular astigmatism, corneal scars, tear film instability, or higher-order aberrations into candidates by removing corneal scars and pterygial tissue with a resultant clear and measurable optical system.
Because many patients have already undergone a LASIK or premium cataract surgery, this technique maintains their optimized vision because LASIK flaps are not distorted, keratitis is not induced, and corneal desiccation/distortion do not occur compared with traumatic techniques or refractively adverse corneal incisions.
We have performed laser vision surgery and implanted multifocal/toric /implantable collamer lenses and even Intacs (Addition Technology) in patients who have undergone the amniotic graft pterygium and pinguecula removal surgery with successful outcomes.
Given the no-cut nature of the grafting procedure, no induced refractive changes occur. Good vision is maintained or even improved by relieving the astigmatism caused by pterygial-induced pull on the cornea.
Despite the consistent results and high patient satisfaction, we place great emphasis on preoperative patient education. Patients are instructed that this is a serious surgical procedure with associated risks. Even with a very low recurrence rate, scarring and worse-looking eyes are possible.
Individual healing patterns play an important role in final outcomes. We suggest caution to surgeons who advertise this procedure under attractive names as We have had numerous patients come to me with complications of these procedures for correction.
One patient who was satisfied with the sparkling white eye postoperatively visited the local eye surgeon who did not see stitches or inflamed red areas postoperatively and tried checking for the graft with a Q-tip across the eye, which removed the glued graft from the eye. The patient returned to me for re-grafting.
The second case was a patient who needed muscle alignment surgery, and the third patient was followed for a localized pupillary shape anomaly that is improving.
All three patients had undergone extensive bitemporal surgery. Although many patients with similar surgical profiles have done very well, we recommend that patients have one lesion removed at a time.
In summary, pterygium and pinguecula surgery can be approached cosmetically, even in extensive cases, and not only improved pathologically and functionally, but also raised to a cosmetic outcome. Additionally, many cases can then benefit from vision correction surgery for associated ammetropia for a concept of “look good and see good!”9-11
In the next column, We will discuss strategies for handling complex and recurrent pterygium surgery and complications, such as scleral melts.
Small Pterygium This lesion can be varied in its appearance from small and pink to large and angry red with symptoms of dry eye, cosmetically unacceptable appearance and or affecting vision adversely.
Large Pterygium Dr. Gulani performs a specialized surgery for this condition and has been cited extensively in news and medical literature for his surgical technique and instrumentation . He performs a complete excision of this lesion with his Iceberg concept followed by an Amniotic membrane (Human Placenta) graft. Dr. Gulani uses no stitches during this surgery and in fact applies glue which has raised the bar in looks and comfort for patients with this disease.
This surgery lately has been included in Dr. Gulani's CORNEOPLASTIQUE™ approach to such eye disorders with a goal for excellent appearance and good vision.
There are various surgical modalities for Pinguecula ie. Eye Bright, I-Brite, Brite Eyes, Amniotic surgery, etc. We encourage patients to do their research and make the selection after discussing with your surgeon.
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