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Collagen Cross-Linking (CXL)

Patient with inherited corneal weakening disorders like keratoconus, keratoglobus, or pellucid marginal degeneration (PMD), including those with surgically weakened corneas from deep Lasik and Radial Keratotomy (RK) surgeries can experience abnormal protrusions (steeping) and in often cases a curvature which results in changes of vision and refractive error.

Collagen Cross-linking (corneal cross-linking, CXL, CCL, C3) is a technology that allows firming of the corneal tissue. Dr. Gulani describes this as turning cellophane paper to plastic, so you can imagine it turning it stronger. Cross-linking involves using specially formulated riboflavin (Vitamin B2) drops along with a special pulsed UV (ultraviolet) light technology that bonds the collagen of the cornea to strengthen and make it more firm.

Dr. Gulani sees a number of patients who have had indiscriminate cross-linking where doctors under a pretense of prevention “locked” in the patient with their disability. Dr. Gulani’s scoliotic spine as seen in this image clearly illustrates that even though pouring cement (CXL) on the spine prevents the spine from bending further, the spine should first be straightened before the application of the cement.


With over three decades of experience with nearly all technologies and protocols of collagen cross-linking Dr. Gulani uses his proprietary technique not only in patients with keratoconus but has successful employed this technology (Peschke, Switzerland) in patients with surgical complications like those following Lasik, RK, HEX-K, and INTACS. Dr. Gulani believes in applying cross-linking when measurement is impossible due to vision fluctuations to prepare for vision corrective surgery or in those cases where following vision corrective surgery on a compromised cornea he wishes to “trap” the successfully acquired vision correction for long term stability.

Crosslinking Complication Correction

With Dr. Gulani’s experience and track record with collagen cross-linking technology and additionally his ability to use it in combination with different vision enhancing and restorative techniques he is a world destination for fixing complication of collagen cross-linking surgery itself. Patients and eye surgeons from around the world refer their patients with collagen cross-linking complications from irregular corneas to uncontrolled keratoconus and blinding scars which he has successfully corrected with his proprietary systems straight to vision.

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8075 Gate Parkway (W)
Suite 102 & 103
Jacksonville, Florida 32216
Phone: (904) 296-7393
Fax: 1-888-397-4699